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April 21, 2022Disease MarkersOpen Access

The Relationship between Intracarotid Plaque Neovascularization and Lp (a) and Lp-PLA2 in Elderly Patients with Carotid Plaque Stenosis

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Why the study?

The relationship between carotid plaque neovascularization and Lp (a) or Lp-PLA2 in elderly patients with carotid plaque stenosis was not well understood.

Comparison

Stable (n=62) vs unstable (n=38) carotid plaque groups

Design

Retrospective study

Authors

CSChang SunNXNa XiXZXinxin Zhang

Discussion

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Overview

May support Lp(a) and Lp-PLA2 as carotid plaque instability biomarkers in elderly patients; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

P
Population
100 elderly patients with carotid plaque stenosis diagnosed from January 2020 to January 2022, divided into stable (n=62) and unstable (n=38) plaque groups.
I
Intervention
Measurement of plasma Lp(a) and Lp-PLA2 levels, and intraplaque angiogenesis assessment by contrast-enhanced ultrasound (CEUS)
C
Comparator
Stable versus unstable carotid plaques
O
Outcome
Relationship between plasma Lp(a) and Lp-PLA2 levels and plaque characteristics (thickness, degree of stenosis) and angiogenesissurrogate

Elevated plasma Lp(a) and Lp-PLA2 levels correlate with intraplaque neovascularization and can serve as biomarkers reflecting carotid plaque instability in elderly patients.

Cite This Study

Sun et al. (2022) studied this question.

synapsesocial.com/papers/6a852fef22ea7ab258b2ea74https://doi.org/10.1155/2022/6154675
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