Comparison of a Fully Automated Immunoassay with a Point-of-Care Testing Method for B-Type Natriuretic Peptide
Why the study?
Does the ACCESS System automated BNP assay provide comparable diagnostic accuracy to the TRIAGE BNP test in patients with heart failure?
Population
305 individuals, comprising 91 healthy individuals and 214 patients with idiopathic or secondary…
Comparison
ACCESS System automated immunochemiluminescent… vs TRIAGE BNP test (Biosite)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May support interchangeable BNP assays for HF diagnosis with method-specific cutoffs; leaves open standardization needs across platforms.
Structured PICO
Does the ACCESS System automated BNP assay provide comparable diagnostic accuracy to the TRIAGE BNP test in patients with heart failure?
P
Population
305 individuals, comprising 91 healthy individuals (51 women, 40 men; mean age 43.2 years) and 214 patients with idiopathic or secondary cardiomyopathy (21 with LVEF >50%). Diagnostic accuracy was evaluated in 193 patients with clinically ascertained heart failure (122 mild NYHA I-II, 71 severe NYHA III-IV).
I
Intervention
ACCESS System (Beckman Coulter) automated immunochemiluminescent assay for B-Type Natriuretic Peptide (BNP)
C
Comparator
TRIAGE BNP test (Biosite)
O
Outcome
Analytical performance (imprecision, detection limit) and diagnostic accuracy (ROC curve analysis) for differentiating healthy persons from patients with heart failuresurrogate
The ACCESS automated BNP assay demonstrates comparable diagnostic accuracy to the TRIAGE test for identifying heart failure, though absolute BNP values are method-dependent and require assay-specific cutoffs.
Limitations
- Decision cutoff values are strictly related to the specific clinical setting comparing healthy persons and patients with clinically ascertained heart failure, rather than routine clinical practice where suspected patients are compared.
Cite This Study
Prontera et al. (2005) studied this question.