September 1, 2003AJP Endocrinology and Metabolism

Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes

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Population

Bovine growth hormone (bGH)-transgenic mice and littermates

Comparison

Bovine growth hormone (bGH) overexpression vs Littermates (non-transgenic)

Design

Preclinical

Authors

BOBob OlssonSahlgrenska University Hospital MBMohammad Bohlooly‐YAstraZeneca (Brazil)OBOla BrusehedSahlgrenska University Hospital

Discussion

Member takes

Implication

GH excess may alter hepatic lipid metabolism in mice; hypothesis-generating for links to cardiovascular risk in acromegaly.

Structured PICO

Population

Bovine growth hormone (bGH)-transgenic mice and littermates

Intervention

Bovine growth hormone (bGH) overexpression

Comparator

Littermates (non-transgenic)

Outcome

Hepatic gene expression (measured via DNA microarray)surrogate

Bovine growth hormone-transgenic mice exhibit marked changes in hepatic metabolic gene expression, offering potential molecular links between elevated GH levels and cardiovascular disease.

Cite This Study

Olsson et al. (2003) studied this question.

synapsesocial.com/papers/6a8530984b2893ddcbc6b244 https://doi.org/10.1152/ajpendo.00444.2002

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Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider