Population
8-month-old bovine GH (bGH)-transgenic mice and control mice
Comparison
Long-term chronic growth hormone excess vs Control mice
Design
Preclinical
Follow-up
8 months (age of mice)
Authors
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GH excess alters lipids in mice; leaves open translation to human GH disorders or therapy.
Long-term growth hormone excess in a transgenic mouse model induces significant alterations in lipid metabolism, characterized by decreased VLDL production and increased degradation.
Frick et al. (2001) studied this question.
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