Why the study?
Does growth hormone affect the production and secretion of apolipoprotein B from rat hepatocytes?
Population
Rat hepatocytes cultured on laminin-rich matrigel in serum-free medium
Comparison
Bovine growth hormone for 1 or 3 days vs 3 nM insulin and 500 microM oleic acid
Design
Preclinical
Follow-up
1 or 3 days
Authors
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Should not change practice; leaves open GH effects on human apoB secretion.
Does growth hormone affect the production and secretion of apolipoprotein B from rat hepatocytes?
Growth hormone directly alters the production and secretion of apoB-containing lipoproteins in rat hepatocytes, increasing apoB-48 and decreasing apoB-100 secretion.
Lindén et al. (2000) studied this question.