December 1, 1992Endocrinology

In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver.

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Population

Perfused livers prepared from cortisol/T3-replaced hypophysectomized female rats

Comparison

Recombinant human growth hormone (hGH) infusion vs Absence of recombinant human growth hormone…

Design

Preclinical

Authors

MEMarshall B. ElamUniversity of Tennessee Health Science Center HWHenry G. WilcoxUniversity of Tennessee at Knoxville SSS. SolomonTufts University

Discussion

Member takes

Implication

Hypothesis-generating for GH regulation of VLDL secretion; requires human studies before any clinical consideration.

Structured PICO

Population

Perfused livers prepared from cortisol/T3-replaced hypophysectomized female rats

Intervention

Recombinant human growth hormone (hGH) infusion

Comparator

Absence of recombinant human growth hormone infusion

Outcome

Rates of secretion of VLDL lipid (triglyceride, phospholipid, and cholesterol) and apoproteinsurrogate

In vivo growth hormone treatment restores VLDL lipid and apoprotein secretion in hypophysectomized rats, suggesting GH regulates VLDL secretion by altering phospholipid and/or apoprotein availability.

Cite This Study

Elam et al. (1992) studied this question.

synapsesocial.com/papers/6a7a20cce357fbdac5895f63 https://doi.org/10.1210/endo.131.6.1446613

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In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider