August 1, 1992Proceedings of the National Academy of SciencesOpen Access

Importance of growth hormone for the induction of hepatic low density lipoprotein receptors.

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Why the study?

Does growth hormone regulate hepatic LDL receptor expression and plasma LDL levels?

Population

Normal rats, hypophysectomized rats, and human gallstone patients undergoing operation

Comparison

Growth hormone administration and estrogen vs Hypophysectomized state without GH in rats…

Design

Preclinical

Authors

MRMats RudlingUppsala University GNGunnar NorstedtLinköping University HOHerbert OlivecronaMay Institute

Discussion

Member takes

Implication

GH may influence LDL metabolism; animal data leave open any human therapeutic role pending trials.

Structured PICO

Does growth hormone regulate hepatic LDL receptor expression and plasma LDL levels?

Population

Normal rats, hypophysectomized rats, and human gallstone patients undergoing operation

Intervention

Growth hormone (GH) administration (12 international units/day in humans) and estrogen (ethynylestradiol 5 mg/kg per day in rats)

Comparator

Hypophysectomized state without GH in rats; baseline or comparison to statin therapy (pravastatin/simvastatin) in humans

Outcome

Hepatic LDL receptor expression/binding activity and serum cholesterol levelssurrogate

Growth hormone plays an important role in the induction of hepatic LDL receptors and may be important for controlling plasma LDL levels in humans.

Cite This Study

Rudling et al. (1992) studied this question.

synapsesocial.com/papers/6a7a20cce357fbdac5895f64 https://doi.org/10.1073/pnas.89.15.6983

View Full Paper

Ask AI

Bookmark

Importance of growth hormone for the induction of hepatic low density lipoprotein receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Importance of growth hormone for the induction of hepatic low density lipoprotein receptors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider