October 1, 1993Proceedings of the National Academy of SciencesOpen Access

Loss of resistance to dietary cholesterol in the rat after hypophysectomy: importance of the presence of growth hormone for hepatic low density lipoprotein-receptor expression.

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Why the study?

Does growth hormone substitution restore hepatic LDL-receptor expression and reduce hypercholesterolemia in hypophysectomized rats fed a high-cholesterol diet?

Population

Normal and hypophysectomized rats

Comparison

2% cholesterol diet for 5 or 6 days, with… vs Normal rats on 2% cholesterol diet…

Design

Preclinical

Follow-up

5 or 6 days

Authors

MRMats RudlingUppsala University BAB. AngelinKarolinska University Hospital

Discussion

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Implication

GH essential for LDL-receptor maintenance in cholesterol-fed hypophysectomized rats; leaves open human translation in hypopituitarism.

Structured PICO

Does growth hormone substitution restore hepatic LDL-receptor expression and reduce hypercholesterolemia in hypophysectomized rats fed a high-cholesterol diet?

Population

Normal and hypophysectomized rats

Intervention

2% cholesterol diet for 5 or 6 days, with stepwise hormonal substitution including growth hormone (GH)

Comparator

Normal rats on 2% cholesterol diet; hypophysectomized rats on 2% cholesterol diet without GH substitution

Outcome

Hepatic low density lipoprotein (LDL)-receptor number, LDL-receptor mRNA levels, plasma cholesterol, and hepatic cholesterolsurrogate

Growth hormone is essential for maintaining hepatic LDL-receptor expression and preventing hypercholesterolemia in response to dietary cholesterol in rats.

Cite This Study

Rudling et al. (1993) studied this question.

synapsesocial.com/papers/6a8ce1e7748301e7973019c4 https://doi.org/10.1073/pnas.90.19.8851

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Loss of resistance to dietary cholesterol in the rat after hypophysectomy: importance of the presence of growth hormone for hepatic low density lipoprotein-receptor expression.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Loss of resistance to dietary cholesterol in the rat after hypophysectomy: importance of the presence of growth hormone for hepatic low density lipoprotein-receptor expression.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider