January 15, 1996Journal of Clinical InvestigationOpen Access

Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I.

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Population

Hypophysectomized rats receiving high-dose ethynylestradiol or challenge with dietary cholesterol…

Comparison

Growth hormone (GH) infusion vs Insulin-like growth factor I (IGF-I) infusion

Design

Preclinical

Authors

MRMats RudlingUppsala University HOH. OlivecronaBaylor University GEGösta EggertsenUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

GH may regulate LDL receptors independently of IGF-I in animals; hypothesis-generating for human dyslipidemia therapies.

Structured PICO

Population

Hypophysectomized rats receiving high-dose ethynylestradiol or challenge with dietary cholesterol, hormonally substituted by infusion with dexamethasone and L-thyroxine

Intervention

Growth hormone (GH) infusion

Comparator

Insulin-like growth factor I (IGF-I) infusion

Outcome

Hepatic LDL receptor expression and plasma lipoprotein levelssurrogate

Growth hormone regulates hepatic LDL receptor expression and plasma lipoprotein levels directly, rather than through an IGF-I mediated pathway.

Cite This Study

Rudling et al. (1996) studied this question.

synapsesocial.com/papers/6a82c3d91a90e54f711c2ccc https://doi.org/10.1172/jci118415

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Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider