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September 1, 1991Circulation

Light and electron microscopic localization of brain natriuretic peptide in relation to atrial natriuretic peptide in porcine atrium. Immunohistocytochemical study using specific monoclonal antibodies.

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Population

5 porcine atria

Design

Preclinical

Authors

KHKoji HasegawaKanazawa UniversityHFHisayoshi FujiwaraHeart Failure / CardiomyopathyHIHiroshi ItohPreventive Cardiology

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Overview

Does not alter natriuretic peptide use in patients; leaves open human relevance of atrial granule heterogeneity.

Structured PICO

P
Population
5 porcine atria
I
Intervention
Immunohistocytochemical localization using specific monoclonal antibodies (light and electron microscopy)
O
Outcome
Immunocytochemical localization of BNP in relation to ANPsurrogate

Demonstrates that atrial myocytes can synthesize both ANP and BNP, with a transmural gradient that may reflect responses to wall stress.

Cite This Study

Hasegawa et al. (1991) studied this question.

synapsesocial.com/papers/6a8534780743ff3319d97e77https://doi.org/10.1161/01.cir.84.3.1203
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation and sequence determination of human brain natriuretic peptide in human atrium1990 · 233 citations
  2. 2Preparation of Monoclonal Antibodies against Brain Natriuretic Peptide and Their Application to Radioimmunoassay and Passive Immunization*1990 · 4 citations
  3. 3Release of atrial natriuretic peptide by atrial distension1985 · 328 citations
  4. 4Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.1989 · 240 citations
  5. 5Ventricular wall stress.1981 · 376 citations