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April 29, 2019Circulation Arrhythmia and ElectrophysiologyOpen Access

Genetic Discovery of ATP-Sensitive K + Channels in Cardiovascular Diseases

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Why the study?

Recent studies in genetically modified animals and genomic analyses in patients have implicated ATP-sensitive K+ channel subtypes in physiological and pathological cardiovascular processes.

Design

Review

Authors

YHYan HuangQilu Hospital of Shandong UniversityDHDan HuNorth Sichuan Medical UniversityCHCongxin HuangElectrophysiology

Discussion

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Overview

May inform genetic research on KATP channels in CVD; leaves open any clinical application.

Structured PICO

P
Population
Human and animal models with cardiovascular diseases related to ATP-sensitive K+ channels
I
Intervention
Genetic changes/modifications in ATP-sensitive K+ channels
O
Outcome
Pathophysiology in the cardiovascular system

This review highlights the causal relationship between genetic changes in ATP-sensitive K+ channels and cardiovascular disease pathophysiology.

Cite This Study

Huang et al. (2019) studied this question.

synapsesocial.com/papers/6a85370fe1eabc68e2929116https://doi.org/10.1161/circep.119.007322
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[ΔN30,K185Q] in the heart2007 · 28 citations
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  3. 3Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP‐sensitive potassium channels subunits in the Ukrainian population2018 · 10 citations
  4. 4Atrial Structural Remodeling Gene Variants in Patients with Atrial Fibrillation2018 · 13 citations