Why the study?
Does modulation of TASK-1 channels alter action potential duration in human atrial cardiomyocytes?
Population
Human heart tissue (atria, auricles, atrio-ventricular node) and human atrial cardiomyocytes
Design
Preclinical
Authors
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May support TASK-1 as atrial-selective AF target; leaves open translation from animal data to clinical trials.
Does modulation of TASK-1 channels alter action potential duration in human atrial cardiomyocytes?
TASK-1 channels are predominantly expressed in human atria and modulate action potential duration, suggesting they could be a specific drug target for atrial fibrillation.
Limberg et al. (2011) studied this question.
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