Why the study?
Does surgical banding of the ascending aorta induce increased stiffness and predispose to congestive heart failure in a pig model?
Does surgical banding of the ascending aorta induce increased stiffness and predispose to congestive heart failure in a pig model?
In a pig model of severe aortic stenosis, increased left ventricular stiffness is the major early pathological abnormality predisposing to heart failure, occurring before any decline in systolic function or relaxation.
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Stiffness may drive early HF risk in pressure-overload models; leaves open translation to human diastolic HF prevention.
Ishikawa et al. (2015) studied this question.
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