Why the study?
Does phospholamban ablation enhance relaxation in murine slow-twitch skeletal muscle?
Population
Isolated, intact soleus muscles from wild-type (WT) and phospholamban (PLB)-deficient mice
Comparison
Phospholamban deficiency and isoproterenol… vs Wild-type (WT) soleus muscles
Design
Preclinical
Authors
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PLB ablation may modulate skeletal muscle relaxation in mice; leaves open translation to human disease or therapy.
Does phospholamban ablation enhance relaxation in murine slow-twitch skeletal muscle?
Phospholamban is a key determinant of relaxation in slow-twitch skeletal muscle under basal conditions and during isoproterenol stimulation.
Slack et al. (1997) studied this question.
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