Population
Mice deficient in Phospholamban (PLB-) generated via targeted ablation in murine embryonic stem cells
Comparison
Targeted ablation of the Phospholamban (PLB) gene vs Wild-type mice
Design
Preclinical
Authors
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Phospholamban ablation attenuates vascular sensitivity in mice; leaves open relevance to human vasomotor disorders or therapies.
Targeted ablation of the phospholamban gene in mice demonstrates its regulatory role in the SR Ca2+ pump and vascular smooth muscle contractility.
Lalli et al. (1997) studied this question.
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