June 1, 1988Journal of Cardiovascular Pharmacology
Effects and Pharmacokinetics of Bolus Injections of Atrial Natriuretic Factor in Normal Volunteers
Why the study?
Does a single bolus injection of atrial natriuretic factor alter hemodynamics, renal function, and endocrine markers in healthy volunteers?
Population
10 healthy volunteers under a 135 mmol/day sodium intake
Comparison
Single intravenous bolus dose of exogenous human… vs Matched vehicle injection
Design
Other
Follow-up
up to 60 minutes
Authors
Discussion
Loading...
Member takes
Implication
Threshold effects at 100 μg in volunteers merit patient studies; leaves open therapeutic utility in disease states.
Structured PICO
Does a single bolus injection of atrial natriuretic factor alter hemodynamics, renal function, and endocrine markers in healthy volunteers?
P
Population
10 healthy volunteers under a 135 mmol/day sodium intake
I
Intervention
Single intravenous bolus dose of exogenous human atrial natriuretic factor (ANF) at doses of 3, 12.5, 25, 50, or 100 μg
C
Comparator
Matched vehicle injection
O
Outcome
Hemodynamic, renal, and endocrine effects, and pharmacokineticssurrogate
In healthy volunteers, intravenous bolus injections of atrial natriuretic factor produce significant hemodynamic and renal effects at a threshold dose of 100 μg, despite dose-dependent increases in cyclic GMP at lower doses.
Cite This Study
Cusson et al. (1988) studied this question.