Key result
A 4.5 micrograms/kg bolus of human atrial natriuretic factor significantly decreased heart rate, right atrial pressure, and pulmonary capillary wedge pressure in congestive heart failure (p<0.05).
Why the study?
Does human atrial natriuretic factor improve hemodynamic parameters in patients with congestive heart failure?
Population
12 patients with congestive heart failure
Design
Case_series
Follow-up
120 minutes
Authors
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Should not change practice; leaves open whether atrial natriuretic factor improves outcomes in heart failure.
Does human atrial natriuretic factor improve hemodynamic parameters in patients with congestive heart failure?
p-value: p=<0.05
High-dose bolus injection of human atrial natriuretic factor safely improves hemodynamic parameters in patients with chronic heart failure.
Giles et al. (1991) studied congestive heart failure (n=12). human atrial natriuretic factor [ANF (102-126)] was evaluated on hemodynamic responses (p=<0.05). A 4.5 micrograms/kg bolus of human atrial natriuretic factor significantly decreased heart rate, right atrial pressure, and pulmonary capillary wedge pressure in congestive heart failure (p<0.05).
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