Why the study?
Do barbiturates reduce arrhythmias during halothane anesthesia without intubation?
Do barbiturates reduce arrhythmias during halothane anesthesia without intubation?
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Barbiturates reduce sinus-bradycardia and supraventricular arrhythmias during halothane anesthesia without intubation; supports their use to suppress vagal tone in this setting.
The effect of barbiturates on cardiac rate and rhythm during halothane anesthesia without intubation was studied in a triple-blind, randomized trial with 28 patients. The test group was premedicated with pentobarbital and induced with thiopental, while the control group was anesthetized with halothane and nitrous oxide only. There was a significant preponderance of sinus-bradycardia and supraventricular disturbances in the control group. It is concluded that the use of barbiturates is advantageous because of their ability to suppress enhanced vagal tone.
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Andersen et al. (1978) studied this question.
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