Why the study?
Does ketamine combined with propofol provide stable anaesthesia compared to propofol and fentanyl in patients undergoing noncardiac surgery?
Does ketamine combined with propofol provide stable anaesthesia compared to propofol and fentanyl in patients undergoing noncardiac surgery?
The combination of propofol and ketamine provides haemodynamically stable total intravenous anaesthesia without significant psychotomimetic side effects for noncardiac surgery.
Answers are grounded in this paper and cite their sources.
May support propofol-ketamine TIVA in noncardiac surgery; leaves open randomized comparison versus propofol-fentanyl.
A prospective study of 18 patients who underwent noncardiac surgery was performed to study the use of ketamine as an analgesic during total intravenous anaesthesia with propofol. A comparison was made with the combination propofol/fentanyl. The propofol/ketamine combination resulted in haemodynamically stable anaesthesia without the need for additional analgesics. Postoperative behaviour was normal in all patients and none of the patients reported dreaming during or after the operation. Propofol seems to be effective in eliminating side effects of a subanaesthetic dose of ketamine in humans. We recommend the propofol/ketamine combination for total intravenous anaesthesia for surgery when stable haemodynamics are required.
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GUIT et al. (1991) studied this question.
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