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January 1, 1993Anesthesiology

Reversal of Volatile Anesthetic-induced Depression of Myocardial Contractility by Extracellular Calcium Also Enhances Left Ventricular Diastolic Function

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Why the study?

Does CaCl2 infusion improve left ventricular systolic and diastolic function in dogs anesthetized with volatile anesthetics?

Population

9 chronically instrumented dogs undergoing 27 experiments with pharmacologic blockade of the autonomic…

Comparison

CaCl2 infusion at 1.25, 2.5, or 5 mg.kg-1 x… vs CaCl2 infusion in the conscious state

Design

Preclinical

Authors

PPPaul S. PagelStructural Heart DiseaseJKJohn P. KampineElectrophysiologyWSWilliam T. SchmelingMarquette University

Discussion

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Implication

Calcium counters volatile anesthetic myocardial depression in dogs; leaves open translation to human perioperative care.

Structured PICO

Does CaCl2 infusion improve left ventricular systolic and diastolic function in dogs anesthetized with volatile anesthetics?

P
Population
9 chronically instrumented dogs undergoing 27 experiments with pharmacologic blockade of the autonomic nervous system
I
Intervention
CaCl2 infusion at 1.25, 2.5, or 5 mg.kg-1 x min-1 during halothane or isoflurane anesthesia
C
Comparator
CaCl2 infusion in the conscious state
O
Outcome
Left ventricular systolic function (myocardial contractility evaluated by Mw) and diastolic function (tau, Kp, dL/dtE, dL/dtA)surrogate

Extracellular calcium reverses volatile anesthetic-induced depression of myocardial contractility and enhances left ventricular diastolic function in a canine model.

Cite This Study

Pagel et al. (1993) studied this question.

synapsesocial.com/papers/6a853f02385dd211e7c2aaechttps://doi.org/10.1097/00000542-199301000-00020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alteration of Left Ventricular Diastolic Function by Desflurane, Isoflurane, and Halothane in the Chronically Instrumented Dog with Autonomie Nervous System Blockade1991 · 93 citations
  2. 2Desflurane and Isoflurane Exert Modest Beneficial Actions on Left Ventricular Diastolic Function during Myocardial Ischemia in Dogs1995 · 41 citations
  3. 3Negative inotropy of halogenated anesthetics in ferret ventricular myocardium1990 · 20 citations
  4. 4Volatile anaesthetic effects on Na<sup>+</sup>‐Ca<sup>2+</sup> exchange in rat cardiac myocytes2001 · 17 citations
  5. 5Isoflurane, but Not Halothane, Improves Indices of Diastolic Performance in Dogs with Rapid Ventricular, Pacing-induced Cardiomyopathy1996 · 30 citations