August 28, 2012PLoS ONEOpen Access

AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction-Induced Heart Failure

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Structured PICO

Population

C57BL/6 mouse model of transverse aortic constriction-induced failing heart (TAC-FH), neonatal rat ventricular cells (NRVCs), and HL-1 cells

Intervention

AAV-mediated HRC knock-down (in vivo) and siRNA-mediated HRC knock-down (in vitro)

Comparator

Control

Outcome

Cardiac function (fractional shortening) and cardiac fibrosissurrogate

Down-regulation of HRC exacerbates cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure by perturbing SR-mediated Ca2+ cycling.

Discussion

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Implication

HRC downregulation may worsen pressure-overload HF in mice; leaves open its therapeutic targeting pending human studies.

Cite This Study

Park et al. (2012) studied this question.

synapsesocial.com/papers/6a853f1c895c7e29f4c6b6fa https://doi.org/10.1371/journal.pone.0043282

Topics

Heart failure HFrEF treatment Echocardiography

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AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction-Induced Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Topics

AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction-Induced Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider