Uncoupling protein‐2 gene polymorphisms are associated with obesity in Hungarian children

AIM: To determine the frequency of common polymorphisms of genes associated with energy metabolism among normal weight and overweight/obese children to look for effects on childhood obesity. METHODS: Among 709 overweight/obese and 637 normal weight children (age 6-17 years), anthropometric measurements were carried out and genotyping for the following gene polymorphisms: β3 -adrenoreceptor Trp64Arg, uncoupling protein (UCP) -1 -3826 A/G, UCP-2 -866 G/A and exon 8 del/ins, UCP-3 -55 C/T and peroxisome proliferator-activated receptor-γ Pro12Ala. RESULTS: On multivariate regression analysis adjusted for age and gender heterozygosity and homozygosity for the UCP-2 -866 A variant was associated with an odds ratio (OR) for obesity of 0.69 (95% CI: 0.52-0.92; p = 0.013) and 0.50 (95% CI: 0.32-0.79; p = 0.003), respectively, compared with G/G homozygotes. Heterozygotes and homozygotes for the UCP-2 exon 8 ins allele had an OR for obesity of 1.66 (95% CI: 1.24-2.23; p = 0.001) and 2.12 (95% CI: 1.23-3.63; p = 0.006), respectively, compared with del/del homozygotes. There were no significant differences in obesity risk in association with the other examined gene polymorphisms. CONCLUSION: Common polymorphisms of the UCP-2 gene might influence the propensity to overweight/obesity in Hungarian children.