Key result
The UCP2 insertion homozygous genotype (II) was significantly more frequent in obese children compared to healthy controls (p=0.0001), identifying it as a risk factor for childhood obesity.
Why the study?
Are UCP2 gene polymorphisms associated with childhood obesity and related metabolic disorders?
Case-Control (n=200)
Are UCP2 gene polymorphisms associated with childhood obesity and related metabolic disorders?
p-value: p=0.0001
UCP2 gene polymorphisms, specifically the insertion homozygous genotype and the -866A allele, are associated with an increased risk of childhood obesity and related metabolic disorders.
Supports genetic research on UCP2 in pediatric obesity; does not support clinical genotyping or practice change.
OBJECTIVE: This study aimed to investigate the possible role of uncoupling protein 2 (UCP2) gene polymorphisms in childhood obesity and related metabolic disorders. METHODS: Obese patients (n=100) and healthy controls (n=100) were analyzed for -866G>A and insertion/deletion (I/D) polymorphisms of the UCP2 gene by polymerase chain raction and/or restriction fragment length polymorphism. RESULTS: UCP2 I/D polymorphism showed an association with obesity. The insertion homozygous genotype (II) was higher in obese patients (p=0.0001), while the DD genotype was higher in controls (p=0.0034). Body mass index and relative weight were lower in patients carrying the A allele of the -866G>A polymorphism (p=0.021 and p=0.047, respectively). There was an association between insulin resistance and -866A allele carrier patients with consanguineous parents (p=0.005). CONCLUSION: Insertion homozygous genotype and the allele of I/D polymorphism were found to be risk factors for childhood obesity and related metabolic disorders. The -866A allele was associated with susceptibility to central adiposity, hypercholesterolemia, hypertriglyceridemia and insulin resistance.
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Balcı et al. (2012) conducted a case-control in Childhood obesity and related metabolic disorders (n=200). UCP2 gene polymorphisms (-866G>A and I/D) vs. Healthy controls was evaluated on Association of UCP2 I/D polymorphism with obesity (p=0.0001). The UCP2 insertion homozygous genotype (II) was significantly more frequent in obese children compared to healthy controls (p=0.0001), identifying it as a risk factor for childhood obesity.
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