Why the study?
Does activated whole blood clotting time (AWBCT) accurately monitor heparin therapy compared to standard coagulation parameters in patients undergoing hemodialysis?
Does activated whole blood clotting time (AWBCT) accurately monitor heparin therapy compared to standard coagulation parameters in patients undergoing hemodialysis?
AWBCT is a simple, inexpensive, and reproducible bedside method that correlates well with WBCT and plasma heparin levels for monitoring heparin therapy.
May support AWBCT for bedside heparin monitoring in hemodialysis; leaves open validation versus APTT in prospective studies.
Twelve patients receiving heparin during hemodialysis had coagulation parameters monitored using the whole blood clotting time (WBCT), activated partial thromboplastin time (APTT), plasma heparin levels and activated whole blood clotting time (AWBCT). The AWBCT, performed with a battery-powered portable incubator/timer, correlated with both the corresponding WBCT and the plasma heparin levels. However, the correlation between the AWBCT and the APTT was quite poor. This assay is simply performed, inexpensive, and reproducible. It is recommended as an excellent method for monitoring heparin therapy.
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Forman et al. (1981) studied this question.
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