January 1, 2003AJP Heart and Circulatory Physiology

Input-size dependence of the baroreflex neural arc transfer characteristics

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Structured PICO

Population

9 anesthetized rabbits

Intervention

Perturbation of isolated carotid sinus pressure using binary white noise with varying input amplitudes (5, 10, 20, and 40 mmHg)

Comparator

Comparison across different input amplitudes (5, 10, 20, and 40 mmHg)

Outcome

Transfer gain at 0.01 Hz and slope of the transfer gain between 0.03 and 0.3 Hzsurrogate

The study demonstrates that a model with a sigmoidal component following a derivative component best explains the overall neural arc transfer characteristics of the baroreflex.

Authors

TKToru KawadaUniversity of Chichester YYYusuke YanagiyaNational Cerebral and Cardiovascular Center KUKazunori UemuraNational Cerebral and Cardiovascular Center

Discussion

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Implication

Nonlinearity in baroreflex gain challenges linear autonomic models; leaves open translation to human cardiovascular disease.

Cite This Study

Kawada et al. (2003) studied this question.

synapsesocial.com/papers/6a854260acfb9ccf0c92944e https://doi.org/10.1152/ajpheart.00319.2002

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Input-size dependence of the baroreflex neural arc transfer characteristics

Structured PICO

Discussion

Implication

Cite This Study

Input-size dependence of the baroreflex neural arc transfer characteristics

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider