June 2, 2004Journal of Cardiovascular Pharmacology

ATP-Sensitive Potassium Channels Are Involved in Adenosine-Induced Reduction of Blood Pressure Variability in Spontaneously Hypertensive Rats

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Population

Conscious unrestrained spontaneously hypertensive rats

Design

Preclinical

Authors

FSFu‐Ming ShenTongji University GZGuoming ZhuZhejiang University CMChao‐Yu MiaoGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Hypothesis-generating for A2-receptor/KATP modulation of BP variability in hypertension models; should not yet change clinical practice.

Structured PICO

Population

Conscious unrestrained spontaneously hypertensive rats

Intervention

Adenosine receptor agonists (adenosine, CPCA, CPA) and ATP-sensitive potassium channel opener (pinacidil) or blocker (glibenclamide)

Outcome

Blood pressure variabilitysurrogate

Adenosine reduces blood pressure variability in spontaneously hypertensive rats via activation of ATP-sensitive potassium channels mediated by the adenosine A2-receptor.

Cite This Study

Shen et al. (2004) studied this question.

synapsesocial.com/papers/6a8544829df997f4bbd6a45e https://doi.org/10.1097/00005344-200407000-00012

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ATP-Sensitive Potassium Channels Are Involved in Adenosine-Induced Reduction of Blood Pressure Variability in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ATP-Sensitive Potassium Channels Are Involved in Adenosine-Induced Reduction of Blood Pressure Variability in Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider