Population
Isolated cat heart preparation
Comparison
Perfusion with Tyrode's solution containing… vs Perfusion with Tyrode's solution alone
Design
Preclinical
Authors
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Adenosine/ATP may mediate coronary vasodilation via uptake in isolated hearts; leaves open human translation and therapeutic relevance.
Adenosine and ATP induce coronary vasodilation and are metabolized to inosine and hypoxanthine in the isolated cat heart, with dinitrophenol likely causing vasodilation via adenosine release.
Jacob et al. (1960) studied this question.
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