Why the study?
Does midbrain or cervical transection alter sympathetic nerve discharge responses to heating in senescent rats?
Population
Chloralose-anesthetized young, mature, and senescent Fischer 344 rats
Comparison
Midbrain-transection or cervical-transection… vs Sham-MT or sham-CT rats
Design
Preclinical
Authors
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Hypothesis-generating for differential forebrain/brainstem control of sympathetic responses in senescence; leaves open human translation.
Does midbrain or cervical transection alter sympathetic nerve discharge responses to heating in senescent rats?
In senescent rats, suppression of splanchnic sympathetic nerve discharge to heating involves forebrain and brain stem neural circuits, while renal suppression is mediated solely by brain stem circuits.
Kenney et al. (2003) studied this question.
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