March 1, 1995Journal of Applied Physiology

Sympathetic nerve responses to hyperthermia in the anesthetized rat

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Population

Chloralose-anesthetized rats (including baroreceptor-innervated and -denervated rats)

Comparison

Progressive increases in core body temperature… vs Baseline temperature (38.0 degrees C)

Design

Preclinical

Authors

MKMichael KenneyThe University of Texas at El Paso CBC. C. BarneyHope College THToshinori HiraiKumamoto University

Discussion

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Implication

Hyperthermia drives multi-bed sympathetic activation independent of baroreflexes in rats; extends animal models but leaves open human translation.

Structured PICO

Population

Chloralose-anesthetized rats (including baroreceptor-innervated and -denervated rats)

Intervention

Progressive increases in core body temperature (Tc) from 38.0 to 41.0 degrees C (hyperthermia)

Comparator

Baseline temperature (38.0 degrees C)

Outcome

Sympathetic nerve discharge (SND) from renal, lumbar, and splanchnic nerves, mean arterial pressure, and heart ratesurrogate

Hyperthermia acts as a potent stimulus to the sympathetic nervous system, increasing activity across multiple regional arterial beds independently of baroreceptor opposition.

Cite This Study

Kenney et al. (1995) studied this question.

synapsesocial.com/papers/6a98f57560c7aa7f93272bd0 https://doi.org/10.1152/jappl.1995.78.3.881

View Full Paper

Ask AI

Bookmark

Implication

Hyperthermia drives multi-bed sympathetic activation independent of baroreflexes in rats; extends animal models but leaves open human translation.

Sympathetic nerve responses to hyperthermia in the anesthetized rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathetic nerve responses to hyperthermia in the anesthetized rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider