What question did this study set out to answer?

To determine whether high-density lipoprotein cholesterol efflux capacity is impaired in systemic lupus erythematosus and whether this impairment is associated with subclinical carotid atherosclerosis.

January 17, 2020Lara D. VeekenOpen Access

Impaired HDL cholesterol efflux capacity in systemic lupus erythematosus patients is related to subclinical carotid atherosclerosis

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To determine whether high-density lipoprotein cholesterol efflux capacity is impaired in systemic lupus erythematosus and whether this impairment is associated with subclinical carotid atherosclerosis.
Enrolled 418 participants in a cross-sectional study, consisting of 195 patients with systemic lupus erythematosus and 223 healthy controls.
Quantified cholesterol efflux capacity using an in vitro macrophage assay and analyzed serum lipoprotein profiles in all participants.
Assessed carotid intima-media thickness and carotid plaque presence via ultrasound in lupus patients, followed by multivariable regression adjusting for cardiovascular risk factors, statins, and disease activity.
Cholesterol efflux capacity was significantly downregulated in lupus patients compared to controls [8.1 (4.2)% vs 16.9 (10.4)%, P = 0.004], independent of traditional cardiovascular risk factors, statin therapy, or disease activity.
Reduced cholesterol efflux capacity was independently and inversely associated with the presence of carotid plaques in systemic lupus erythematosus [odds ratio 0.87 (95% CI: 0.78, 0.97), P = 0.014].

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Implication

Cross-sectional study reveals impaired cholesterol efflux capacity is associated with carotid plaques in lupus, indicating HDL dysfunction drives subclinical atherosclerosis.

Cite This Study

Sánchez‐Pérez et al. (2020) studied this question.

synapsesocial.com/papers/6a85466daf90e4b27242eccd https://doi.org/10.1093/rheumatology/keaa038

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Implication

Cross-sectional study reveals impaired cholesterol efflux capacity is associated with carotid plaques in lupus, indicating HDL dysfunction drives subclinical atherosclerosis.

Impaired HDL cholesterol efflux capacity in systemic lupus erythematosus patients is related to subclinical carotid atherosclerosis

Key Points

Discussion

Implication

Cite This Study

Impaired HDL cholesterol efflux capacity in systemic lupus erythematosus patients is related to subclinical carotid atherosclerosis

Key Points

Discussion

Implication

Cite This Study

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