What question did this study set out to answer?

To determine whether HDL cholesterol efflux capacity differs between patients with systemic lupus erythematosus and those with rheumatoid arthritis.

August 8, 2020Arthritis Care & Research

Differences in Capacity of High‐Density Lipoprotein Cholesterol Efflux Between Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis

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To determine whether HDL cholesterol efflux capacity differs between patients with systemic lupus erythematosus and those with rheumatoid arthritis.
Assessed 460 participants (195 patients with systemic lupus erythematosus and 265 with rheumatoid arthritis) for serum lipoprotein concentrations and cholesterol efflux capacity using an in vitro assay.
Performed multivariable regression analysis adjusting for traditional cardiovascular risk factors, statin use, disease-related variables, and disease-associated lipid profile differences.
Cholesterol efflux capacity was significantly downregulated in patients with systemic lupus erythematosus compared to rheumatoid arthritis (β = -12, 95% CI [-13, -10], P < 0.001), independent of traditional cardiovascular risk factors and lipid levels.
Patients with rheumatoid arthritis displayed a more proatherogenic conventional lipid pattern, presenting with lower HDL cholesterol and higher apolipoprotein B serum concentrations than patients with lupus.

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Implication

Comparative study reveals greater impairment of HDL cholesterol efflux capacity in lupus than rheumatoid arthritis, suggesting distinct autoimmune drivers of cardiovascular risk.

Cite This Study

Quevedo-Abeledo et al. (2020) studied this question.

synapsesocial.com/papers/6aaca82c493a6464efc0d12d https://doi.org/10.1002/acr.24407

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Implication

Comparative study reveals greater impairment of HDL cholesterol efflux capacity in lupus than rheumatoid arthritis, suggesting distinct autoimmune drivers of cardiovascular risk.

Differences in Capacity of High‐Density Lipoprotein Cholesterol Efflux Between Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis

Key Points

Discussion

Implication

Cite This Study

Differences in Capacity of High‐Density Lipoprotein Cholesterol Efflux Between Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis

Key Points

Discussion

Implication

Cite This Study

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