Population
Astrocytes
Comparison
Atrial natriuretic peptide (ANP) and C-ANP 4-23 vs Mitogens alone
Design
Preclinical
Authors
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Should not yet inform clinical use of ANP analogs; leaves open translation of clearance-receptor signaling to human vascular disease.
ANP inhibits growth factor-stimulated MAPK activity via the natriuretic peptide clearance receptor, providing a potential mechanism for its anti-proliferative actions.
Prins et al. (1996) studied this question.
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