What question did this study set out to answer?

Determine cerebral blood flow and brain perfusion rate in anesthetized rats using the uptake kinetics of an intravenous tracer.

May 1, 1958American Journal of Physiology-Legacy Content

Cerebral Blood Flow in the Rat

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Authors

LSLeo A. SapirsteinAmes Research Center GHGordon E. HanusekCalifornia State University Los Angeles

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Implication

Experimental study reveals a brain perfusion rate of 0.51 ml/gm/min in anesthetized female rats, indicating equivalent whole-body and cerebral tracer extraction ratios.

Key Points

Determine cerebral blood flow and brain perfusion rate in anesthetized rats using the uptake kinetics of an intravenous tracer.
Administered a single intravenous injection of radiolabeled iodoantipyrine (I-131) in anesthetized rats.
Tracked cerebral uptake over time to determine tracer stabilization and calculated cerebral blood flow as the product of cardiac output and fractional cerebral uptake.
Tracer levels in the brain stabilized within 7–9 seconds and remained constant for 64 seconds, showing equal extraction ratios between the brain and body.
Cerebral perfusion rate was determined to be 0.51 ml/gm/min in female rats.

Cite This Study

Sapirstein et al. (1958) studied this question.

synapsesocial.com/papers/6a8546f99df997f4bbd6a59c https://doi.org/10.1152/ajplegacy.1958.193.2.272

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Implication

Experimental study reveals a brain perfusion rate of 0.51 ml/gm/min in anesthetized female rats, indicating equivalent whole-body and cerebral tracer extraction ratios.

Cerebral Blood Flow in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Cerebral Blood Flow in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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