What question did this study set out to answer?

To measure regional blood flow rates in the anterior and posterior lobes of the rat pituitary gland and assess vascular permeability.

August 1, 1958American Journal of Physiology-Legacy Content

Determination of Blood Flow to the Rat Pituitary Gland

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Authors

HGHarold GoldmanHarvard University LSLeo A. SapirsteinAmes Research Center

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Implication

Animal study demonstrates differential blood perfusion between pituitary lobes in rats, indicating that the blood-brain barrier does not extend into the gland.

Key Points

To measure regional blood flow rates in the anterior and posterior lobes of the rat pituitary gland and assess vascular permeability.
Administered a radioactive rubidium-86 (Rb 86) tracer to pentobarbitalized rats.
Measured tissue uptake kinetics over time to determine perfusion rates and evaluate blood-brain barrier presence.
The posterior lobe showed a perfusion rate of 3.6 ml/gm/min.
The anterior lobe demonstrated a minimum perfusion rate of 0.59 ml/gm/min and a maximum of 0.90 ml/gm/min.
Rubidium-86 uptake patterns matched non-nervous tissue, indicating the blood-brain barrier does not extend into either pituitary lobe.

Cite This Study

Goldman et al. (1958) studied this question.

synapsesocial.com/papers/6a738be88e3434b3274e644e https://doi.org/10.1152/ajplegacy.1958.194.2.433

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Implication

Animal study demonstrates differential blood perfusion between pituitary lobes in rats, indicating that the blood-brain barrier does not extend into the gland.

Determination of Blood Flow to the Rat Pituitary Gland

Discussion

Member takes

Implication

Key Points

Cite This Study

Determination of Blood Flow to the Rat Pituitary Gland

Discussion

Member takes

Implication

Key Points

Cite This Study

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