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May 25, 2020Oxidative Medicine and Cellular LongevityOpen Access

Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice

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Why the study?

Gender influences cardiac aging characteristics, but gender-dependent cardiac fibrosis occurring with age remains largely not elucidated.

Population

Aged male and female mice

Comparison

Aged male vs aged female mice

Design

Animal comparative study

Authors

AAAngela AchkarTufts UniversityYSYouakim SalibaSaint Joseph UniversityNFNassim FarèsSaint Joseph University

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Implication

Sex differences may shape age-related cardiac fibrosis management; leaves open clinical translation of this novel preclinical finding.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Achkar et al. (2020) studied this question.

synapsesocial.com/papers/6a8548ec3cde6ee03eb2ec3bhttps://doi.org/10.1155/2020/8282157
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Also Consider

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  1. 1Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling2015 · 281 citations
  2. 2Collagen accumulation in heart ventricles as a function of growth and aging1989 · 183 citations
  3. 3Sex-Specific Cardiovascular Structure and Function in Heart Failure with Preserved Ejection Fraction2014 · 245 citations
  4. 4Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survival2019 · 79 citations
  5. 5Age-Related Left Ventricular Remodeling and Associated Risk for Cardiovascular Outcomes2009 · 380 citations