November 1, 1995Critical Care Medicine

Parenteral magnesium sulfate versus amiodarone in the therapy of atrial tachyarrhythmias

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Why the study?

Does intravenous magnesium sulfate improve the conversion of acute atrial tachyarrhythmias to sinus rhythm compared to amiodarone in critically ill patients?

Population

42 critically ill patients with atrial tachyarrhythmias, mean age 67 +/- 15 years, mean APACHE II score 22…

Comparison

Magnesium sulfate 0.037 g/kg intravenous bolus… vs Amiodarone 5 mg/kg intravenous bolus and 10…

Design

RCT, Randomly allocated

Follow-up

24 hours

Authors

JMJohn L. MoranUniversity of Ulster JGJohn D. GallagherUniversity of Southern California SPSandra PeakeAustralian and New Zealand Intensive Care Society

Discussion

Member takes

Implication

Magnesium may be preferred over amiodarone for acute conversion in critically ill patients; extends RCT evidence for magnesium in tachyarrhythmias.

Structured PICO

Does intravenous magnesium sulfate improve the conversion of acute atrial tachyarrhythmias to sinus rhythm compared to amiodarone in critically ill patients?

Population

42 critically ill patients (21 medical, 21 surgical) with atrial tachyarrhythmias (ventricular response rate >= 120 beats/min sustained for >= 1 hr), mean age 67 +/- 15 years, mean APACHE II score 22 +/- 6.

Intervention

Magnesium sulfate 0.037 g/kg (37 mg/kg) intravenous bolus followed by 0.025 g/kg/hr (25 mg/kg/hr) infusion, administered after correction of plasma potassium to >= 4.0 mmol/L.

Comparator

Amiodarone 5 mg/kg intravenous bolus and 10 mg/kg/24-hr infusion, administered after correction of plasma potassium to >= 4.0 mmol/L.

Outcome

Conversion to sinus rhythm over 24 hours.surrogate

Intravenous magnesium sulfate is superior to amiodarone for the acute conversion of atrial tachyarrhythmias to sinus rhythm in critically ill patients.

Cite This Study

Moran et al. (1995) studied this question.

synapsesocial.com/papers/6a854ab08018c50ef23d9656 https://doi.org/10.1097/00003246-199511000-00005

View Full Paper

Ask AI

Bookmark

Implication

Magnesium may be preferred over amiodarone for acute conversion in critically ill patients; extends RCT evidence for magnesium in tachyarrhythmias.

Parenteral magnesium sulfate versus amiodarone in the therapy of atrial tachyarrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Parenteral magnesium sulfate versus amiodarone in the therapy of atrial tachyarrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider