Why the study?
Do patients undergoing continuous ambulatory peritoneal dialysis have increased markers of atherosclerosis and inflammation compared to healthy subjects?
Do patients undergoing continuous ambulatory peritoneal dialysis have increased markers of atherosclerosis and inflammation compared to healthy subjects?
Patients undergoing continuous ambulatory peritoneal dialysis have increased carotid intima-media thickness, arterial stiffness, and inflammatory markers compared to healthy controls, suggesting a higher risk of atherosclerosis.
Answers are grounded in this paper and cite their sources.
May indicate elevated CV risk in CAPD patients; leaves open causality and requires prospective confirmation.
Objective: Cardiovascular disease is an important cause of morbidity and mortality in patients with renal failure. Patients with chronic renal failure are significantly susceptible to atherosclerosis. In the present study, we aimed to investigate the effect of elevated homocysteine on atherosclerosis and inflammation in continuos ambulatory peritoneal dialysis (CAPD) patients. Methods: 56 patients undergoing CAPD and 27 healthy subjects was enrolled in the study. All patients total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, hs-CRP, homocysteine, intima-media thickness, arterial stiffness values were measured and statistically analyzed. Results: It is determined that the levels of total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, homocysteine, intima-media thickness, arterial stiffness and hs-CRP was higher in patients compared to the control group (in order; p=0.03, p=0.0006, p=0.02). Conclusion: Carotid intima-media thickness being increased because of increased levels of homocysteine and inflammation in CAPD patients. Therefore, in case of atherosclerosis, hyperlipidemia and inflammation more aggressive treatment protocol should be considered. Patients with elevated plasma homocysteine concentrations should be treated.
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Fatih Şahpaz (2016) studied this question.
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