Why the study?
Are elevated homocysteine levels associated with increased atherosclerosis and inflammation markers in patients undergoing continuous ambulatory peritoneal dialysis compared to healthy subjects?
Are elevated homocysteine levels associated with increased atherosclerosis and inflammation markers in patients undergoing continuous ambulatory peritoneal dialysis compared to healthy subjects?
Patients undergoing continuous ambulatory peritoneal dialysis exhibit higher levels of homocysteine and markers of atherosclerosis and inflammation compared to healthy controls.
Answers are grounded in this paper and cite their sources.
Higher homocysteine and atherosclerosis markers in CAPD may signal CV risk; hypothesis-generating and should not change practice.
Objective: Cardiovascular disease is an important cause of morbidity and mortality in patients with renal failure. Patients with chronic renal failure are significantly susceptible to atherosclerosis. In the present study, we aimed to investigate the effect of elevated homocysteine on atherosclerosis and inflammation in continuos ambulatory peritoneal dialysis (CAPD) patients. Methods: 56 patients undergoing CAPD and 27 healthy subjects was enrolled in the study. All patients total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, hs-CRP, homocysteine, intima-media thickness, arterial stiffness values were measured and statistically analyzed. Results: It is determined that the levels of total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, homocysteine, intima-media thickness, arterial stiffness and hs-CRP was higher in patients compared to the control group (in order; p=0.03, p=0.0006, p=0.02). Conclusion: Carotid intima-media thickness being increased because of increased levels of homocysteine and inflammation in CAPD patients. Therefore, in case of atherosclerosis, hyperlipidemia and inflammation more aggressive treatment protocol should be considered. Patients with elevated plasma homocysteine concentrations should be treated.
No takes yet. Share an insight, caveat, or question.
Fatih Şahpaz (2016) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: