Why the study?
Does debrisoquine treatment alter the responsiveness of plasma aldosterone to angiotensin II infusion in normal subjects and patients with mild essential hypertension?
Population
24 individuals (11 normal subjects and 13 patients with mild essential hypertension)
Comparison
Debrisoquine treatment for 4 weeks, with… vs Baseline (before debrisoquine treatment)
Design
Cohort
Follow-up
4 weeks
Authors
Loading...
Indicates loss of sympathetic modulation of aldosterone response in hypertension; hypothesis-generating and requires prospective confirmation before clinical consideration.
Does debrisoquine treatment alter the responsiveness of plasma aldosterone to angiotensin II infusion in normal subjects and patients with mild essential hypertension?
The sympathetic nervous system exerts an inhibitory influence on aldosterone responsiveness to angiotensin II in normal individuals, a physiological interaction that appears impaired in mild essential hypertension.
Beretta-Piccoli et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: