Sympathetic Nervous System in Heart Failure
Population
Murine model and patients with heart failure
Design
Editorial
Authors
Discussion
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Member takes
Implication
This editorial highlights evidence linking the absence of sympathoinhibitory 2 adreno-receptors to worsened heart failure outcomes, supporting the mechanistic link between sympathetic nervous system activation and poor prognosis.
Structured PICO
P
Population
Murine model and patients with heart failure
I
Intervention
Absence of sympathoinhibitory 2 adreno-receptors / deletion polymorphism of the 2 receptor
O
Outcome
Overactive catecholamine release, aggressive remodeling of the left ventricle, worsening signs of heart failure, and shortened life expectancy
This editorial highlights evidence linking the absence of sympathoinhibitory 2 adreno-receptors to worsened heart failure outcomes, supporting the mechanistic link between sympathetic nervous system activation and poor prognosis.
Limitations
- The number of animals is small
- Surgical mortality is neither addressed nor accounted for
Cite This Study
Jay N. Cohn (2002) studied this question.