Although chlorine dioxide and ozone are good disinfecting agents, the health effects of their reaction products are incompletely understood. The chlorite ion produced by chlorine dioxide and oxidized organic compounds resulting from ozonation may be toxic. Until or unless these substances are identified and their safety demonstrated, neither chlorine dioxide nor ozone should be substituted for chlorine in water disinfection.
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Arnold E. Greenberg (1981) studied this question.
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