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September 1, 1996ASAIO Journal

In Vivo Observation of Cavitation on Prosthetic Heart Valves

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Why the study?

Does decreasing pump filling increase prosthetic heart valve cavitation in an in vivo calf LVAD model?

Population

2 calves implanted with Pennsylvania State University Left Ventricular Assist Devices using Björk-Shiley…

Comparison

Decreased pump filling by increasing beat rate vs Normal pump filling

Design

Preclinical

Follow-up

44 days

Authors

CZConrad M. ZapantaDSDavid R. StinebringDSD. S. Sneckenberger

Discussion

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Overview

Low pump filling may increase hemolysis via cavitation in LVAD models; extends preclinical data but leaves open human relevance.

Structured PICO

Does decreasing pump filling increase prosthetic heart valve cavitation in an in vivo calf LVAD model?

P
Population
2 calves implanted with Pennsylvania State University Left Ventricular Assist Devices (LVADs) using Björk-Shiley Monostrut 27 mm (mitral) and 25 mm (aortic) valves with Delrin occluders
I
Intervention
Decreased pump filling by increasing beat rate
C
Comparator
Normal pump filling
O
Outcome
Cavitation intensity measured by the root mean square (RMS) value of the mitral pressure signal during a 5 ms interval after valve closuresurrogate

In vivo measurement using high-fidelity pressure transducers confirms that prosthetic heart valve cavitation occurs and increases with decreased pump filling, transiently affecting plasma hemoglobin.

Cite This Study

Zapanta et al. (1996) studied this question.

synapsesocial.com/papers/6a855cb035bc0eada8d59897https://doi.org/10.1097/00002480-199609000-00047
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Method for Real-Time In Vitro Observation of Cavitation on Prosthetic Heart Valves1994 · 34 citations
  2. 2In Vivo Demonstration of Cavitation Potential of a Mechanical Heart Valve1999 · 29 citations
  3. 3Cavitation Dynamics of Mechanical Heart Valve Prostheses1994 · 50 citations
  4. 4Effect of Systolic Duration on Mechanical Heart Valve Cavitation in a Pneumatic Ventricular Assist Device: Using a Monoleaflet Valve2008 · 3 citations
  5. 5Observation and Quantification of Cavitation on a Mechanical Heart Valve with an Electro-Hydraulic Total Artificial Heart2006 · 4 citations