Why the study?
Thrombus and pannus formations commonly cause bileaflet mechanical heart valve leaflet dysfunction, a life-threatening complication whose induced downstream aortic flow disturbances and detection methods required investigation.
Can analysis of normalized axial velocity profiles detect and differentiate configurations of bileaflet mechanical heart valve dysfunction in an experimental model?
Population
Experimental model of the ascending aorta with a bileaflet mechanical heart valve
Comparison
Several configurations of leaflet dysfunction vs normal valve function
Design
Experimental in vitro study using time-resolved planar particle image velocimetry
Authors
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Normalized axial velocity analysis may enable noninvasive detection of mechanical valve dysfunction; leaves open clinical translation from this animal model.
Can analysis of normalized axial velocity profiles detect and differentiate configurations of bileaflet mechanical heart valve dysfunction in an experimental model?
Analysis of normalized axial velocity profiles in the ascending aorta can detect and differentiate configurations of bileaflet mechanical heart valve dysfunction in an experimental model, suggesting a potential approach using phase-contrast MRI.
Darwish et al. (2019) studied this question.
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