What question did this study set out to answer?

To evaluate the safety, efficacy, and clinical factors influencing long-term oral anticoagulant therapy in an elderly population.

January 1, 1988Age and Ageing

Long-Term Oral Anticoagulant Therapy in Elderly Patients

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Why the study?

Does concomitant drug therapy affect anticoagulant control and complications in elderly patients on long-term oral anticoagulants?

Population

49 patients aged 65-89 years receiving long-term oral anticoagulant therapy.

Design

Cohort

Follow-up

6 months to 6 years (mean 3.9 years)

Authors

LWLahiru WickramasingheUniversity of Winnipeg SBSripurna BasuSt Bartholomew's Hospital SBSanchit BansalJadavpur University

Discussion

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Implication

Concomitant drugs were associated with poorer control in elderly warfarin users; hypothesis-generating for medication review trials.

Key Points

To evaluate the safety, efficacy, and clinical factors influencing long-term oral anticoagulant therapy in an elderly population.
Followed 49 patients aged 65–89 years receiving long-term oral anticoagulants for 6 months to 6 years (mean 3.9 years; 195 patient years).
Analyzed the relationship between anticoagulant control, complications, and treatment failures against demographic, clinical, and pharmacological variables.
Anticoagulant control was significantly correlated with concomitant drug therapy (P < 0.001), with poorer control observed in patients receiving drugs known to potentiate warfarin and those with frequent drug regimen changes.
Five patients experienced six non-fatal haemorrhages (two major and four minor), all displaying poor anticoagulant control from the outset (P < 0.01), with an overall treatment failure rate of 4%.
Control quality, complications, and treatment failures did not vary by age, sex, social status, mobility, visual acuity, domiciliary supervision, or anticoagulation indication.

Structured PICO

Does concomitant drug therapy affect anticoagulant control and complications in elderly patients on long-term oral anticoagulants?

Population

49 patients aged 65-89 years receiving long-term oral anticoagulant therapy.

Intervention

Long-term oral anticoagulant therapy (warfarin) for 6 months to 6 years (mean 3.9 years).

Outcome

Efficacy of anticoagulant control, occurrence of complications (haemorrhages), and treatment failures.safety

In elderly patients on long-term oral anticoagulants, concomitant drug therapy significantly impacts anticoagulant control, highlighting the need for careful medication management to prevent poor control and subsequent haemorrhages.

Cite This Study

Wickramasinghe et al. (1988) studied this question.

synapsesocial.com/papers/6a855eec9df929a58fad9871 https://doi.org/10.1093/ageing/17.6.388

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Long-Term Oral Anticoagulant Therapy in Elderly Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Long-Term Oral Anticoagulant Therapy in Elderly Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider