Effects of haemorrhage on the distribution of the peripheral blood flow in the rabbit
Population
Unanaesthetized rabbits
Comparison
Bleeding by 26% of blood volume vs Comparison between normal animals, animals…
Design
Preclinical
Follow-up
4 hours
Authors
Discussion
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Implication
Supports baroreflex-driven regional vasoconstriction in animal hemorrhage; leaves open translation to clinical hypovolemic shock.
Structured PICO
P
Population
Unanaesthetized rabbits (normal, animals without functioning autonomic effectors, and animals with section of the carotid sinus and aortic nerves)
I
Intervention
Bleeding by 26% of blood volume
C
Comparator
Comparison between normal animals, animals without functioning autonomic effectors, and animals with section of carotid sinus and aortic nerves
O
Outcome
Blood flow and vascular resistance in the portal, renal, muscle and skin bedssurrogate
This preclinical study demonstrates that arterial baroreceptors mediate differential regional reflex vasoconstriction following hemorrhage in rabbits, with the greatest effects in the renal bed.
Cite This Study
Chalmers et al. (1967) studied this question.