Fever in Malignant Neoplastic Disease: A Controlled Study of Tetracycline Therapy

Article1 October 1960FEVER IN MALIGNANT NEOPLASTIC DISEASE: A CONTROLLED STUDY OF TETRACYCLINE THERAPYDANE R. BOGGS, M.D., EMIL FREI III, M.D., CHARLES H. ZIERDT, M.S.DANE R. BOGGS, M.D.Search for more papers by this author, EMIL FREI III, M.D.Search for more papers by this author, CHARLES H. ZIERDT, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-4-754 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONFever, in the absence of demonstrable infection, occurs frequently in patients with malignant neoplastic disease. Its pathogenesis is obscure. Occult bacterial infection1, 2, 3has not been excluded as a cause of such fever. While the availability of antibiotics has reduced morbidity and possibly prolonged survival in patients with malignant neoplastic disease, the decision as to whether they should be used in patients with fever without demonstrable infection remains a difficult and controversial one. Such fever frequently disappears with antibiotic therapy,1, 3but this may be a function of the natural duration of the fever, rather than a therapeutic...Bibliography1. SilverUtzFreiMcCullough RTJPENB: Fever, infection and host resistance in acute leukemia, Am. J. Med 24: 25, 1958. CrossrefMedlineGoogle Scholar2. SingerStergman HAF: Pyrexia in gastric carcinoma, Am. J. Digest. Dis. 3: 731-736, 1936. CrossrefGoogle Scholar3. Reich C: Erythromycin as an aid in the therapy of acute leukemia, New York State J. Med. 54: 2208, 1954. MedlineGoogle Scholar4. BoggsFrei DRE: Clinical studies of fever and infection in malignant neoplastic disease, Cancer, in press. Google Scholar5. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication March 7, 1960.From the Chemotherapy Service, General Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.†Present address: Department of Medicine, University of Utah, Salt Lake City, Utah.Requests for reprints should be addressed to Emil Frei, III, M.D., National Cancer Institute, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe New Fluorinated Quinolones for Infection Prevention in Acute LeukemiaLOWELL S. YOUNG, M.D.Ecological Impacts of Antibacterial Agents: Stockholm, March 7–8, 1986Current status of prophylaxis of infection with protected environmentsTrimethoprim-Sulfamethoxazole and Bacterial Infections During Leukemia TherapyLOWELL S. YOUNG, M.D.Spinal cord involvement in leukemia: A review of the literature and a case of Ph1 + acute myeloid leukemia presenting with a conus medullaris syndromeTransfusion of Neutrophils as Prevention or Treatment of Infection in Patients with NeutropeniaStudies of a patient isolator unit and prophylactic antibiotics in cancer chemotherapy. General techniques and preliminary resultsFever and Elevated Erythrocyte Sedimentation Rate1Use of antibiotics in cancer and leukemia 1 October 1960Volume 53, Issue 4Page: 754-764KeywordsAntibioticsFeversHyperthermiaInfectious diseasesLymphomaMorbidityPathogenesisSaltsStaphylococcus aureusTetracyclines ePublished: 1 December 2008 Issue Published: 1 October 1960 PDF downloadLoading ...