Population
Rabbit reticulocyte lysate and COS-7 cells
Design
Preclinical
Authors
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No immediate clinical implications; leaves open IRES role in c-myc regulation in human disease.
This study provides the first demonstration of IRES-dependent translation for a proto-oncogene, suggesting a mechanism for c-myc expression activation under specific cellular stimuli.
Nanbru et al. (1997) studied this question.
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