Key result
The c-Src mRNA contains an internal ribosome entry site (IRES) that enables eIF2-independent translation initiation, exhibiting enhanced activity during cellular stress.
Population
Cell-free translation system, hepatoma-derived cells, and purified HeLa 40 S ribosomal subunit
Design
Preclinical
Authors
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Suggests stress-responsive c-Src upregulation in cancer; leaves open validation in human tumors and therapeutic relevance.
The discovery of an IRES in c-Src mRNA reveals a novel stress-induced regulatory mechanism for c-Src synthesis, potentially explaining its overexpression in cancer.
Allam et al. (2009) studied Cancer. c-Src IRES-mediated translation was evaluated on c-Src mRNA translation mechanism and IRES activity. The c-Src mRNA contains an internal ribosome entry site (IRES) that enables eIF2-independent translation initiation, exhibiting enhanced activity during cellular stress.
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