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June 1, 1993Journal of VirologyOpen Access

Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism

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Population

Cultured cells and in vitro translation systems

Design

Preclinical

Authors

CWChao WangBeijing Tongren HospitalPSPeter SarnowStanford UniversityASAleem SiddiquiUniversity of California, San Diego

Discussion

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Implication

No immediate clinical implications for HCV; leaves open IRES targeting as a research avenue in preclinical models.

Structured PICO

P
Population
Cultured cells and in vitro translation systems
I
Intervention
Dicistronic and monocistronic expression vectors, RNA transfections, and deletion mutagenesis of the HCV 5' noncoding region (NCR)
O
Outcome
Translational control and internal ribosome entry site (IRES) function

Demonstrates that human hepatitis C virus RNA translation is mediated by an internal ribosome entry site within the 5' noncoding region.

Cite This Study

Wang et al. (1993) studied this question.

synapsesocial.com/papers/6a12ed4e13ab6312a8c0bb0ehttps://doi.org/10.1128/jvi.67.6.3338-3344.1993
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus.1982 · 107 citations
  2. 2Internal ribosome entry site within hepatitis C virus RNA1992 · 926 citations
  3. 3Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions1991 · 479 citations
  4. 4Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.1991 · 427 citations
  5. 5The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation1992 · 83 citations