The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation
Population
in vivo and in vitro models studying encephalomyocarditis virus (EMCV) mRNA translation initiation
Comparison
Sequence context modifications around the EMCV… vs Different sequence contexts
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Animal data on EMCV IRES context should not guide therapy; leaves open applicability to human viral translation.
Structured PICO
P
Population
in vivo and in vitro models studying encephalomyocarditis virus (EMCV) mRNA translation initiation
I
Intervention
Sequence context modifications around the EMCV initiation codon (AUG-11)
C
Comparator
Different sequence contexts (e.g., presence/absence of adenine at -3 position)
O
Outcome
Efficiency of internal translation initiationsurrogate
The sequence context around the EMCV initiation codon AUG-11, specifically an adenine at the -3 position, modulates the efficiency of internal translation initiation.
Cite This Study
Davies et al. (1992) studied this question.